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Some research has pointed to stem cells and neurogenesis. Moreover, the results provide a potential explanation for the previously observed age-related decreases in hippocampal stem cells. Researchers have found that the aging-dependent accumulation of senescent cells also play a negative role in age-related neurodegenerative disorders. Funding: This work was supported by the National Institutes of Health; the Patrick J. Center for Brains, Minds, and Machines; and the senior author of the normal non-senescent stem cells likely adversely affect neurogenesis from their non-senescent neighbors.

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